Olefin metathesis of peptide derivatives in dynamic combinatorial chemistry

ORGN 138

Tammy K. C. Low and Eric Enholm, enholm@chem.ufl.edu. Department of Chemistry, University of Florida, Gainesville, FL 32611
The use of olefin metathesis in dynamic combinatorial chemistry is of interest as a method in generating a library of cyclic peptidomimetics. Several peptide derivatives possessing diene functionality were synthesized and subjected to Grubbs' second generation catalyst. Various conditions, such as substrate and catalyst concentrations, as well as different templates, were explored.
 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006