Synthesis of unsymmetrical chiral salens

ORGN 80

Caroline Burd, gtg312j@mail.gatech.edu1, Michael Holbach, michael.hobach@chemistry.gatech.edu1, Xiaolai Zheng, xiaolai.zheng@chemistry.gatech.edu1, Christopher W. Jones, cjones@che.gatech.edu2, and Marcus Weck, marcus.weck@chemistry.gatech.edu1. (1) School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332-0400, (2) School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332
The importance of salen ligands in catalysis makes them an interesting target for immobilization strategies for the potential use in supported catalysis. However, efforts in supported salen complexes are hampered by the lack of a straight-forward synthetic strategies towards unsymmetric functionalized salen ligands. We will present a novel one-pot synthetic approach to unsymmetric salen ligands. As proof of principles for our one-pot strategy, we will present the synthesis of a variety of mono-functionalized salen ligands containing alkyl-based linkers and phenol, alcohol, thioacetate or olefin-based terminal functionalities.
 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006