ORGN 594 |
| Our efforts have focused upon developing various carbohydrate-substituted poly(para phenyleneethynylenes) (PPEs) for rapid-response detection methods of the viral haemagglutinin of influenza. PPEs have unique sensory properties that make them ideal “field” detectors over time-consuming immunoassay techniques. The major synthetic studies have involved forming thioglycosides and thiosialates for attachment to a primary alcohol on ethylene glycol side chain linker of the PPE monomer. Ultimately, the goal of this research is to perform in-vivo sensing studies with both the free lectin in solution and cultured cells to evaluate the usefulness of the PPE as a quantitative analytical tool and as a fluorescent marker for imaging in light microscopy. Eventually, this research could lead to better detection of airborne diseases such as SARS or the bird flu.
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
