ORGN 246 |
| The design, synthesis, and study of novel chiral ligands for metals offer new opportunities in the development of reaction processes leading to useful building blocks for chemical synthesis. We have been investigating chiral dienes as ligands in reactions involving organometallic intermediates and will demonstrate the potential utility of these ligands in several different processes. Additionally, we will present new readily available atropisomeric P,N-ligands (PINAP) which bear structural similarity and reactivity parallels to QUINAP. They are conveniently prepared and resolved as well as easily amenable to structural and electronic modifications. We describe their syntheses and applications in reactions involving Rh-, Ag-, and Cu-catalysts, demonstrating their utility. For the Cu-catalyzed coupling of acetylenes and imines they are found to be superior to QUINAP, affording products with the highest enantioselectivity reported to date. |
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ACS Award in Organometallic Chemistry
8:55 AM-12:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Georgia Ballroom 2, Oral
Division of Organic Chemistry |