ORGN 169 |
| The marine biotoxin azaspiracid is a structurally intriguing molecule featuring an ABCD ring segment that comprises a trioxodispiroketal fused with a tetrahydrofuran. In preliminary studies towards the synthesis of 1, we have observed that treatment of the cyclopropane—alkene 2 with iodonium dicollidine perchlorate (IDCP) provided the tricyclic product 3 corresponding to the BCD ring system of 1. The incorporation of this result into a synthesis of the ABCD segment of 1 will be presented.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
