ORGN 83 |
| Chirality is very important in pharmaceutical products. The specific stereochemistry of a drug gives the drug its functionality. For example, one enantiomer may cause harm or may be non-affective, were as the other enantiomer, functions in the treatment of the ailment. For this reason, it is important to be able to synthesize primarily one enantiomer. The research done involves the synthesis of a chiral auxiliary, which can undergo cleavage of its side chain readily, but still produce products in a high diastereoselectivity. The investigation of diastereoselectivities of various aldol addition reactions and conjugate addition reactions will be explored. The chiral auxiliary then will be applied towards the total synthesis of tolterodine (Detrol LA) a potent competitive muscarinic receptor antagonist designed for the relief of urinary urge incontinence. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |