ORGN 488 |
| Catalytic C-C bond forming reactions arising from C-H bond activations are relatively rare. An innovative approach to achieving such reactions has been achieved by creating a general, Pd-catalyzed method for a catalytic coupling of C-H and C-Hal bonds. The catalytic processes for which we have preliminary results are unique transformations that often can not be achieved by using other methodology. For example, a catalytic coupling of nonactivated secondary sp3 C-H bonds with aryl iodides has been demonstrated. This method provides new and efficient methodology for performing synthetic transformations and may have a significant impact on C-C bond formation methodology, complementing well-known methods like Stille, Kumada and Suzuki couplings. |
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Metal-Mediated Reactions and Syntheses
1:00 PM-5:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C302, Oral
Division of Organic Chemistry |