ORGN 557 |
| The palladium-catalyzed coupling of R-H and R-X bonds has been investigated. The use of pyridine-containing directing groups has resulted in a general method for γ-arylation of sp3 C-H bonds in amine derivatives and β-arylation of sp3 C-H bonds in carboxylic acid derivatives. Additionally this methodology has resulted in a very general method for the arylation of various directing-group containing arenes. For example, both sp3 and sp2 C-H bonds in pyridines and amides may be arylated by using Pd(OAc)2 as a catalyst. |
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |