Conjugate additions: A new dimension for an old reaction using free radical chemistry

ORGN 427

Mukund P. Sibi, Mukund.Sibi@ndsu.edu, Department of Chemistry, North Dakota State University, Ladd Hall, Fargo, ND 58105
Development of new strategies to access enantiomerically pure compounds is at the forefront of synthetic organic chemistry. In this context, chiral Lewis acid catalysis has emerged as one of the premiere methods to control stereochemistry. Michael addition, a.k.a. conjugate addition, is among the top ten transformations in synthetic organic chemistry. This presentation will illustrate how one can use this venerable reaction in new ways to prepare enantiomerically pure organic compounds. Synthesis of amino acids and carbon-carbon bond formation using radical intermediates will be highlighted.
 

George A. Olah Award in Hydrocarbon or Petroleum Chemistry
8:10 AM-12:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Georgia Ballroom 2, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006