ORGN 251 |
| We focus on the development of novel chemically based tools to decipher signal transduction pathways on a genome-wide scale. We've developed a method for producing small molecules that are specific for any protein kinase of interest in a signaling cascade by combining protein design with chemical synthesis. These highly specific inhibitors of individual kinases have revealed a number of new principles of signal transduction that have complemented genetic and biochemical studies of cell signaling. Another area of interest is the tracing of direct kinase substrates. We've designed and synthesized unnatural ATP analogs, which are substrates of our engineered kinases but are poorly accepted as substrates of wild-type kinases. This specific nucleotide substrate of any kinase of interest allows for the radiolabeling of the direct substrates of a wide variety of protein kinases including both serine/threonine and tyrosine kinases. |
|
ACS Award in Pure Chemistry
8:00 AM-12:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |