Arylation of ortho-positions in benzoic acids by using C-H activation methodology

CHED 350

Olafs Daugulis and Quynh Pham. Department of Chemistry, University of Houston, 136 Fleming Building, Houston, TX 77204
The goal of this project is the development of new C-C bond formation reactions based on C-H activation. After modification of reaction conditions, a method developed in our group was applied to the arylation of unprotected carboxylic acids. ortho-Arylation was successful for a variety of benzoic acids. This method is very tolerant with respect to functional groups on both the acid moiety and aryl iodide. For example, bromide substituent is tolerated on both components of this reaction.