ORGN 249 |
| Modern organic synthesis depends heavily on the use of catalysts for selective transformations. We have discovered a class of synthetic peptides that catalyze a number of enantio- and site-selective selective reactions, including group transfers, azide conjugate additions and C-C bond forming processes. This lecture will describe the discovery and use of oligomers containing histidine and thiazolylalanine for various asymmetric bond formations. The connections between peptide sequence and stereoselectivity will be explored in a range of mechanistically distinct reactions. Prospects for generalizations and eventual design of catalysts from first principles will be evaluated. |
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ACS Award in Pure Chemistry
8:00 AM-12:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |