ORGN 468 |
| Each year, many promising natural products are identified as being biologically active in cell culture assays. Despite the proven in vitro efficacies of these compounds, development of these ‘drug candidates' into clinically useful therapeutic agents is an arduous procedure, often due to issues unrelated to the compound's mechanism of action (e.g. poor pharmacokinetics, unfavorable side effects, etc.). While many of these compounds have limited therapeutic potential, investigation of their mechanism of action can provide new information about complex intracellular signaling pathways. Moreover, these studies can serve as the starting point for the rapid development of additional efficacious compounds having more favorable pharmacological profiles. In addition, we have recently developed a new chemical genetic strategy for the identification of key components of intracellular processes.
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Modern Natural Products Chemistry and Drug Discovery
1:25 PM-5:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |