A simple and efficient synthesis of pyrroles

ORGN 289

Surya K De, skd125@yahoo.com and Richard A Gibbs, skd125@pharmacy.purdue.edu. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907
Pyrroles are very important compounds because of their pharmacological properties. Despite their importance from pharmacological, industrial, and synthetic point of views, comparatively few methods for their preparation have been reported. I wish to report a convenient and efficient method for the synthesis of substituted pyrroles by the condensation of amines and 1,4-diketones in the presence of a catalytic amount of scandium triflate at room temperature. Results of this study will be presented.
 

New Reactions and Methodology
1:00 PM-5:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C301, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006