Fluorescent naphthalimide imaging agents for microscopy

CHED 396

Robyn L. Laskowski, laskowrl@uwec.edu, Department of Chemistry, University of Wisconsin - Eau Claire, Eau Claire, WI 54702, Andrew J. Wagner, wagneraj@uwec.edu, Department of Chemisty, University of Wisconsin-Eau Claire, Eau Claire, WI 54701, and David E. Lewis, lewisd@uwec.edu, Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, WI 54702.
Naphthalimides are highly fluorescent compounds, with emission maxima near 500-550 nm, that have recently been exploited as imaging agents in live cells. The aminonaphthalimides, in particular, are useful imaging agents due to their large (typically close to 100 nm) Stokes shifts, and their resistance to photochemical bleaching. We have prepared a series of naphthalimide derivatives whose localization characteristics permit selective visualization of mitochondria, Golgi apparatus, lysosomes, and cholesterol rafts. In an effort to prepare imaging agents with more useful emission characteristics, we have been exploring the synthesis of new naphthalimide derivatives. Progress in the development of new agents will be discussed.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006