ORGN 540 |
| TMEDA/hydrocarbon solvent solutions containing an equivalent of chlorobenzene afford a unique reaction when treated with n-BuLi. Yields of about 40% of dimethylaniline are possible under certain conditions. The benzyne intermediate also reacts with certain o-lithio aryl intermediates to form biphenyls. This sequence possesses the potential to retain the resulting 2'-lithio intermediate to provide a site for further derivatization:
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
