ORGN 641 |
| The chromoprotein Neocarzinosatin comprises a highly reactive enediyne chromophore that is non-covalently bound to an apo-protein. The 113mer apo-protein contains a hydrophobic binding pocket which maintains binding efficacy with a range of substates based on the natural chromophore. This prolific binding has been in the exploited to non-covalently protect chlorambucil and melphalan via tethering to ligands based on the natural chromophore and flavone-based ligands. A wide range of flavone-based substrates can be readily accessed using Pd-mediated reactions from their corresponding bromides and triflates. The synthesis of the apo-protein using native chemical ligation via both two- and three- fragment strategies is also discussed.
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Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
8:00 AM-12:00 PM, Thursday, 30 March 2006 Georgia World Congress Center -- C301, Oral
Division of Organic Chemistry |
