Natural products as leads to potential drugs: An old process or the new hope for drug discovery?

ORGN 467

David J. Newman, dn22a@nih.gov, Natural Products Branch, National Cancer Institute-Frederick, Fairview Center, Suite 206, P. O. Box B, Frederick, MD 21702
Though the use of natural products as leads to drugs waned in the early 1980s with the rise of combinatorial chemistry as a putative discovery tool, inspection of the chemical literature shows that natural products in one guise or another are alive and well and the “chemical inspiration” from these privileged structures is leading to novel approaches in drug design and discovery. This presentation gives a brief historical overview as to why this is so and then will proceed to some recent exemplars in order to “set the stage” for the subsequent presentations in this symposium.
 

Modern Natural Products Chemistry and Drug Discovery
1:25 PM-5:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C303/304/305, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006