Regioselectivity in methylene-free intermolecular enyne metathesis

ORGN 496

Amol A. Kulkarni, aak5@acsu.buffalo.edu and Steven T. Diver, diver@buffalo.edu. Department of Chemistry, University at Buffalo, The State University of New York, 560 Natural Sciences Complex, Amherst, NY 14260
Intermolecular tandem enyne metathesis involving substituted cyclopentenes and terminal alkynes will be described. This reaction affords an expedient synthesis of substituted cycloheptadienes which can be used as versatile building blocks in synthesis. The impact of the intramolecular chelation and our results regarding the chemo- and regioselectivity in these reactions will be presented. Current attempts to further functionalize the cyclodienes will be discussed.

 

Metal-Mediated Reactions and Syntheses
1:00 PM-5:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C302, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006