ORGN 301 |
| The importance of triphosphates and their analogues in DNA sequencing and enzyme and inhibition studies has led to various approaches for their synthesis, none of them wholly satisfactory for a wide range of alcohols and none of them suitable for use in a library synthesis. To address this issue, a supported phosphorylation reagent has been developed. The use of polystyrene based supports allows direct access to phosphonate mono and diesters, which could be oxidized to their phosphate esters. The effect of the nature of the solid support on the chemistry was studied and is discussed with respect to the synthesis of nucleoside triphosphates. |
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Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-5:20 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C302, Oral
Division of Organic Chemistry |