ORGN 285 |
| This presentation will discuss the development and application of new chemical probes for studying complex biological systems. In the area of signal transduction, new strategies including the preparation of synthetic and semi-synthetic protein probes for interrogating the specific function of proteins involved in directed cell migration and cell cycle control have been developed. Due to the essential signalling roles played by intracellular kinase-mediated phosphorylation in key cellular processes, the focus of these studies is on protein kinases as strategic targets. Access to chemical probes to monitor phosphorylation events will enable us to define the spatial and temporal characteristics of protein kinases and phosphoprotein mediators in complex cellular pathways. These probes include both environment-sensitive and chelation-enhanced fluorophores for interrogating phosphorylation-dependent protein-protein interactions and caged phosphoamino acids for examining phosphorylation-mediated cellular functions. |
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Ronald Breslow Award for Achievement in Biomimetic Chemistry
1:15 PM-5:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |