ORGN 126 |
| The synthesis and photochemical investigation of a number of photoisomerizable metal-binding ligands will be presented. This new class of molecule is designed to act as a photoactivated artificial metalloprotease. Trans to cis photoisomerization moves the carboxyl group of an ester or amide close to a metal-bound water molecule, leading to hydrolysis. Synthesis, photochemical characterization, hydrolysis kinetics and yields for reaction products will be reported. The scope of this reaction, potential for photolabile protection of alcohols and amines, and possible applications will be discussed. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |