ORGN 635 |
| The yeast one-hybrid and two-hybrid systems are designed to investigate protein-DNA and protein-protein interactions, respectively. However, these two interactions are usually intertwined in vivo, and in some cases, protein-protein interaction is a prerequisite to protein-DNA interaction. Although the intertwinement may be dissected and investigated, it can be difficult, if not impossible, to detect individual interaction by the use of available techniques. In order to address this question, a modified yeast system was developed to simultaneously study relevant protein-DNA and protein-protein interactions using the basic region/leucine zipper (bZIP) protein family as a model. |
|
Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
8:00 AM-12:00 PM, Thursday, 30 March 2006 Georgia World Congress Center -- C301, Oral
Division of Organic Chemistry |