ORGN 414 |
| Cell permeable small molecules with the ability to bind the major groove of DNA are attractive candidates for controlling gene expression. The paucity of small molecules that bind the major groove of DNA renders the approach of using known DNA binding ligands as a platform for rational drug design impractical. To overcome this hurdle, we are developing a DNA-templated approach to develop ligands that bind sequence selectively to the major groove of DNA. We are synthesizing amino-formyl modified nucleosides and peptide nucleic acids as monomers to evolve a thermodynamically favored ligand with the ability to bind DNA in a sequence specific fashion. To promote recognition along a predefined sequence, we are synthesizing tris(heteroleptic) transition metal complexes as DNA intercalators to promote polymerization at a defined position in the DNA target. The generality of this approach will allow unparalleled flexibility in targeting DNA sequences and will provide additional avenues for targeting diseases on the genomic level. |
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New Reactions and Methodology, Bioorganic Chemistry, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |