Studies toward the total synthesis and absolute configurational determination of (+)-varitriol

ORGN 158

Ryan T. Clemens, cleme001@bama.ua.edu, Department of Chemsitry, University of Alabama, 500 Campus Drive, Tuscaloosa, AL 35487-0336 and Michael P. Jennings, jenningm@bama.ua.edu, Department of Chemistry, University of Alabama, 500 Campus Drive, Tuscaloosa, AL 35487-0336.
First isolated from the marine derived strain of the fungus Emericella variecolor in 2002 by Barrero, varitriol (1) represents a potent anti-tumor agent which exhibited significant cytotoxic activity (mg/ml) against RXF 393 (renal cancer), T-47D (breast cancer), and SNB-75 (CNS cancer) human carcinoma cell lines. In addition to the impressive levels of biological activity, the highly unique and somewhat simple structure of 1 makes it an attractive target for total synthesis. Towards this end, synthetic strategies aimed at the total synthesis of 1 will be discussed in greater detail.
 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006