ORGN 250 |
| A hallmark of cancerous cells is their ability to resist the natural signals of programmed cell death, or apoptosis. This apoptotic evasion is due to mutations in or aberrant expression levels of a variety of proteins in the apoptotic cascade. While these alterations generally enable the cancerous cells to resist pro-apoptotic signals, the elevated levels of some of these proteins also offers an opportunity in targeted cancer therapy. In this lecture the strategy of selectively “turning on” key pro-apoptotic proteins will be discussed. The discovery of small molecules that have this effect in vitro and in cell culture will be described, and the efficacy of such compounds in mouse models of cancer will be detailed. |
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ACS Award in Pure Chemistry
8:00 AM-12:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |