ORGN 174 |
| The 9-methoxy substituted indole alkaloids, mitragynine and 9-hydroxymitragynine have been isolated from Mitragyna Speciosa Korthand, the plant material of which has been used in Thailand as an opioid substitute for pain relief. Both these alkaloids have demonstrated potent analgesic activity. Progress toward the total synthesis of these 9-methoxy-Corynanthe-type indole alkaloids will be presented. The bisindole, 10-hydroxysambarensine, has been isolated from the root bark of Strychnos usambarensis. In vitro tests of this bisindole on two strains of Plasmodia falciparum malaria have demonstrated it is more than twice as active against the chloroquine resistant strain than the drug sensitive one. This is of interest in the treatment of malaria and the mechanism of drug resistance. Progress toward the total synthesis of this antimalarial bisindole will be presented.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
