Development of organocatalysts for Michael addition of aldehydes to enones

ORGN 76

Yonggui Chi, ychi@chem.wisc.edu, Timothy J. Peelen, and Samuel H. Gellman. Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706
Asymmetric organocatalysis has become a prominent area of investigation in recent years. This paper describes the use of imidazolidinones and diphenylprolinol methyl ethers as enantioselective organocatalysts for Michael addition of aldehydes to enones; and a rapid enantiomeric excess assay for α-substituted aldehydes. Future catalyst development and application of organocatalytic reactions will be discussed.

 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Sci-Mix

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006