Linchpin methodology in all-E polyene construction: Towards the fecapentaenes, potent mutagens

CHED 429

Bruce H. Lipshutz, lipshutz@chem.ucsb.edu1, David B. Ball, dball@csuchico.edu2, and Tanya D. Hilger2. (1) Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, (2) Department of Chemistry, California State University, Chico, Chico, CA 95929-0210
Linchpin methodology of organometallic conjunctive reagents has been effectively utilized in rapidly constructing biomolecules containing extensive conjugation. The all E- chiral 12 and 14-fecapentaenes are two target molecules of this organometallic, Pd(0) catalyzed cross-coupling methodology. Construction of a chiral glycerol enol ether coupling partner and a new, non-stannylated conjunctive reagent will be presented.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006