ORGN 636 |
| The basic region/leucine zipper (bZIP) is the simplest protein structure for targeting specific DNA sequences. We have found a minimalist bZIP protein based on yeast GCN4 that can not only recognize its native sequence, but can also target mammalian and vertebrate gene-regulatory sequences naturally bound by basic region/helix-loop-helix (bHLH) proteins. In addition, the DNA-bZIP protein interaction does not always follow the same mechanism as binding to native yeast sequences. This extended use of the bZIP structure may provide a new design strategy for protein-based drugs, especially for designing transcription factors to manipulate cellular functions. |
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Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
8:00 AM-12:00 PM, Thursday, 30 March 2006 Georgia World Congress Center -- C301, Oral
Division of Organic Chemistry |