ORGN 99 |
| Recently the non-mevalonte (methylerythritol phosphate, MEP) pathway was discovered in bacteria and plant chloroplasts for biosynthesis of isoprenoids. The genes, enzymes, and intermediates of this pathway have been established over past few years. Experiments with 13C and /or 2H-labeled precursors were crucial in the elucidation of this route. The chemical synthesis of MEP pathway intermediates and labeled derivatives are also very important in the investigation of biosynthesis of isoprenoids in bacteria and plants. Here the synthesis of methylerythritol phosphate, its cyclodiphosphate, C-methylthreitol phosphate, and deuterium-labeled and amino analogs of MEP pathway intermediates is discussed.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
