Microwave deprotection of aromatic 2-methyl-3-butyn-2-ols

CHED 431

Ashley A. Sullivan, ashleys-06@sandiego.edu1, Christopher Allen, cmallen@ucla.edu2, and Peter M. Iovine, piovine@sandiego.edu1. (1) Department of Chemistry, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, (2) Department of Chemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095
The microwave deprotection of select aromatic 2-methyl-3-butyn-2-ol alkynes has been investigated. The reaction has been optimized for temperature, solvent, time, and base. Reaction times are generally less than two minutes, yields are high for a broad spectrum of substrates, and workup of the crude reaction mixtures is straightforward.

 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006