ORGN 26 |
| A new and efficient catalytic method for addition of enolsilanes to ketones has been developed. Reactions are promoted by silver fluoride salts in the presence of accessible, modular peptide ligands. Catalytic asymmetric aldol additions deliver the desired tertiary alcohols in up to 96% ee and >90% isolated yield. Notable aspects of screening studies leading to optimal catalysts, the scope and limitations of this method and related mechanistic insights, as well as applications to target oriented synthesis will be presented.
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Asymmetric Reactions and Syntheses
8:00 AM-11:40 AM, Sunday, 26 March 2006 Georgia World Congress Center -- C302, Oral
Division of Organic Chemistry |
