Parallel synthesis of coumarin derivatives via hydroarylation

ORGN 309

Jon A. Tunge, tunge@ku.edu and Kelin Li, kelinli@ku.edu. Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, 2010 Malott Hall, Lawrence, KS 66045
Hydroarylation of propiolic esters and cinnamic acids is an atom-economical route to coumarin and dihydrocoumarin core structures. Sequential Pd(II)-catalyzed hydroarylation/Pd(0)-catalyzed cross coupling reactions allow the rapid synthesis of derviatized coumarins. Synthetic and mechanistic aspects of these reactions will be discussed.