De novo synthesis of a stable epoxypyranyl molybdenum scaffold and its use in asymmetric synthesis

ORGN 550

Ethel Garnier, egarnie@emory.edu and Lanny S. Liebeskind. Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322
One of the major challenges in contemporary organic chemistry is the design and execution of concise approaches to biologically active targets. A conceptual approach to enantiocontrolled bond construction in complex organic systems is the use of single enantiomers of organometallic complexes as “organometallic chirons”, from which single enantiomers of complex organic structures can be elaborated in novel and useful ways. We have probed the scope and utility of a novel, stable epoxypyranyl molybdenum scaffold and its use in synthesis. This particular epoxide represents a fascinating platform for further stereospecific functionalizations.