ORGN 284 |
| Signalling in the brain is for the most part chemical; small molecule neurotransmitters are released into the synapse where they bind to neuroreceptors, proteins embedded in the surface membranes of neurons. Binding of neurotransmitter – or any of a number of neurologically active drugs – induces a structural change in the receptor, converting it to an active form that propagates neuronal signalling. Using a combination of organic chemistry, molecular biology, electrophysiology, and computer modelling we have probed these complex membrane proteins with a precision and subtlety normally associated with small molecule studies. We have uncovered key interactions that allow agonists to bind, and that distinguish binding of natural ligands from binding of substances of abuse. We have also identified the essential switch, the conformational change that is induced by agonist binding and that directly leads to opening the ion channel that is part of the receptor.
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Ronald Breslow Award for Achievement in Biomimetic Chemistry
1:15 PM-5:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C303/304/305, Oral
Division of Organic Chemistry |