Progress on the synthesis of pyrrole containing natural products from marine organisms

ORGN 432

John T. Gupton, jgupton@richmond.edu, Department of Chemistry, University of Richmond, Gottwald Science Center, Richmond, VA 23173
For some time our research group has examined the use of vinylogous iminium salts as key building blocks for the synthesis of heterocyclic compounds. In recent years our focus has turned to pyrrole natural products derived from marine organisms. Examples of such compounds include lukianol A, lamellarin O, ningalin B and polycitone A and B. These compounds have been shown to exhibit interesting antitumor activity as well as multidrug resistant reversal activity. Ongoing work in our group relating to the synthesis and biological activity of this class of pyrrole natural products will be presented.
 

ACS Award for Research at an Undergraduate Institution
8:00 AM-12:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C303/304/305, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006