ORGN 612 |
| During the past decade, peroxynitrite has been extensively studied due to its potential important role in biology and medicine. The pathogenesis of many human diseases has been proposed to be linked to the production and reactions of peroxynitrite. However, the short half-life of peroxynitrite in biological system precludes its direct isolation. So far the evidences for the role of peroxynitrite in vivo are all indirect and based largely upon detection of 3-nitrotyrosine in injured tissues.To facilitate the studies of peroxynitrite in biological systems, we have developed a novel fluorescent probe to directly detect peroxynitrite based on PET (photoinduced electron transfer) mechanism without the need of scavengers and inhibitors. We found that non-fluorescent probe efficiently reacted with peroxynitrite under physiological conditions to give a strong fluorescent signal. This finding will provide a powerful tool to evaluate the role of peroxynitrite in various processes.
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Materials, Devices, and Switches
8:00 AM-12:00 PM, Thursday, 30 March 2006 Georgia World Congress Center -- Georgia Ballroom 2, Oral
Division of Organic Chemistry |
