Compound scale-up at the discovery-development interface

ORGN 182

Antonia Nikitenko, nikitea@wyeth.com, Chemical and Screening Sciences, Wyeth, 401 N. Middletown Rd., Pearl River, NY 10965 and John R. Potoski, potoskj@wyeth.com, Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd., Pearl River, NY 10965.
There are many criteria that influence the scale-up efforts of leads at the late discovery stage. While these efforts have a lot in common with typical chemical development, there are some differences. Descriptive case studies will be presented to illustrate these points and show the impact of synthetic chemistry in the transit of discovery leads into full development.