Condensation of amino acids to form peptides in aqueous solution induced by the oxidation of sulfur(IV): An oxidative model for prebiotic peptide formation

ORGN 638

Fei Chen, chenf@hku.hk, Department of Chemistry, The University of Hong Kong, Pokfumlam Road, Pokfulam, Hong Kong, Hong Kong and Dan Yang, yangdan@hku.hk, Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong, China.
Condensation reaction is one of the most important reactions for life, and contributes to the formation of most important biopolymers, i.e., proteins, polysaccharides, and nucleic acids. The condensation of small organic molecules to form macromolecules in prebiotic environment is believed to be a vital step during the origin of life, and the condensation of amino acids to form peptides is one of the key processes. Up to now, successful explanations for plausible prebiotic peptide formation pathways are limited. Here we report that the oxidation of sulfur (IV) can induce the condensation reaction of carboxylic acids and amines to form amides, and the condensation reaction of amino acids to form peptides. This might be a general reaction contributing to prebiotic peptide formation.