The Fu Suzuki reaction, a room-temperature variant of the classic Suzuki coupling reaction using P(t-Bu)₃ and a palladium source, was employed for the key carbon-carbon bond forming step in the kilogram-scale preparation of a clinical candidate.  Thus the thermally-sensitive o-cyanophenylboronic acid 1 was coupled with aryl bromide 2 in high yield and purity at room temperature to afford late-stage pharmaceutical intermediate 3 on multigram and kilogram scale.  Reaction enablement, optimization, general and substrate-specific scope and limitations will be detailed, and other findings encountered while implementing this methodology on kilogram scale will be presented.