ORGN 77 |
| Morita-Baylis-Hillman (MBH) reaction, which involves forming new C-C bonds and generating highly functionalized chiral allylic alcohols, has received considerable interest in organic synthesis. Therefore, not surprisingly, a considerable amount of effort has been devoted to the development of catalytic, enantioselective versions of the processes. However, discovering catalytic systems for asymmetric MBH reactions has proven to be a synthetic challenge, and to date, a very limited number of successful chiral catalysts have been demonstrated for this process. Recently, we have identified a novel binaphthyl-derived amine thiourea bifunctional organocatalyst for catalyzing asymmetric version of the process with achieving up to 94% ee. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |