ORGN 298 |
| The pharmaceutical and fine chemical industries are exploring many routes to improve the cleanliness and efficiency of synthetic processes. One such approach, which is attracting a large amount of interest, is the application of continuous flow micro reaction technology that enables reactions to be performed more rapidly, efficiently and selectively than batch-scale reactions. In this presentation a number of chemical reactions will be used to illustrate the advantages that micro reactors offer for the rapid optimisation of reactions, in which the products are always produced in both higher yield and purity. It will be illustrated that it is possible to generate highly unstable intermediates in situ within the reactor, which may be subsequently reacted to produce more complex products. In addition, the incorporation of a wide variety of solid supported reagents, catalysts and scavengers has been investigated, which simplifies work-up procedures often enabling more pure products to be generated. |
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Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-5:20 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- C302, Oral
Division of Organic Chemistry |