ORGN 637 |
| A group of small molecule inhibitors and inactivators of PAD4 have been successfully synthesized and tested. Some of these small molecules are reversible competitive inhibitors of PAD4; whereas others are irreversible inactivators of PAD4 with IC50 values in the low micromolar range. These molecules are the most potent PAD4 inhibitors and/or inactivators that have ever been reported. Optimization based on these molecules will give rise to more potent and selective PAD4 inhibitors/inactivators that can ultimately be used as treatments for Rheumatoid Arthritis and Multiple Sclerosis.
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Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
8:00 AM-12:00 PM, Thursday, 30 March 2006 Georgia World Congress Center -- C301, Oral
Division of Organic Chemistry |