| MEDI | Sunday, 28 August 2005 | ||
7:00 PM-9:00 PM Washington DC Convention Center -- Hall A, Poster | |||
Poster Session | |||
| Sponsored by Eli Lilly | |||
| Organizer: | David Rotella | ||
| 25 | 6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists Wanying Sun, Lovji D. Cama, Elizabeth Birzin, Sudha Warrier, Louis Locco, Ralph Mosley, Milton M. Hammond, Susan P. Rohrer | ||
| 26 | 4,8-Disubstituted 2-phenyl-quinolines as potent and selective estrogen receptor β ligands An T. Vu, Stephen T. Cohn, Eric S. Manas, Heather A. Harris, Richard E. Mewshaw | ||
| 27 | 4-Hydroxy-N-phenyl substituted phthalimides as selective estrogen receptor beta (ERb) ligands John W. Ullrich, Robert R. Singhaus Jr., Raymond Unwalla, Heather A. Harris | ||
| 28 | Synthesis and deuterium-labeling of pure SERM acolbifene (EM-652.HCl, SCH 57068.HCl) glucuronides Jean-yves Sancéau, Denis Larouche, Brigitte Caron, Patrick Bélanger, Agnčs Coquet, Alain Bélanger, Sylvain Gauthier, Fernand Labrie | ||
| 29 | Dihydrobenzoxathiin SERAMs: Discovery of an optimized antagonist side chain and application of novel side chains to existing SERM platforms Timothy A. Blizzard, Frank DiNinno, Jerry D. Morgan II, Helen Y. Chen, Jane Y. Wu, Seongkon Kim, Wanda Chan, Elizabeth T. Birzin, Yi Tien Yang, Lee Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Ralph T. Mosley, Paula M.D. Fitzgerald, Nandini Sharma, Susan P. Rohrer, James M. Schaeffer, Milton L Hammond | ||
| 30 | Discovery of tissue-selective osteoanabolic SARMs Jiabing Wang, Carol A. McVean, David B. Whitman, Mark E. Duggan | ||
| 31 | New ligands for estrogen receptors Jelena M. Janjic, Miranda Sarachine, Claire Coleman, Peter Wipf, Billy W. Day | ||
| 32 | Discovery of (4-phenylsulfanyl-phenoxy)-acetic acids as a novel class of PPARδ agonists Rajiv Sharma, Jonathan Houze, Joshua Gergely, Michelle Akerman, Frank Kayser, Jean Danao, Jurgen Lehmann | ||
| 33 | Design, synthesis, and SAR of indane acetic acid derivatives: A new class of dual PPAR alpha/gamma agonists Hai-Jun Zhang, Neil Bifulco, Ken Boakye, William Bullock, Thomas Claus, Philip Coish, Miao Dai, Fernado E. Dela Cruz, David Dickson, Ann Gore-Willse, Dongping Fan, Helena Hoover-Lilly, Tindy Li, Derek B. Lowe, Margit MacDougall, Gretchen Mannelly, Mary-Katherine Monahan, Ingo Mugge, Stephen O'Connor, Mareli Rodriguez, Tatiana Shelekhin, Laurel Sweet, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Kake Zhao, Qian Zhao, Jian Zhu, Manami Tsutsumi, Robert Schoenleber | ||
| 34 | 6-(Arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as nonsteroidal progesterone receptor antagonists Jeffrey C. Kern, Eugene A. Terefenko, Andrew Fensome, Ray J Unwalla, Jay Wrobel, Zhiming Zhang, Yun Zhu, Jeffrey Cohen, Richard Winneker, Puwen Zhang | ||
| 35 | Stable analogs of retinamides derived from TTNPB Victoria V. Abzianidze, Michael D. Collins, Nirca J. Nieves, Margaret Clagett-Dame, Robert W. Curley Jr. | ||
| 36 | Synthesis of novel heterocyclic amino acids and their incorporation into somatostatin analogs Audrey Kelleman, Michael S. VanNieuwenhze, Murray Goodman | ||
| 37 | New macrocycles as high affinity antagonists to the motilin receptor Eric Marsault, Sylvie Beaubien, Kamel Benakli, Robert Déziel, Graeme Fraser, Hamid R. Hoveyda, Annick Landry, Luc G. Ouellet, Mark L. Peterson, Carl Saint-Louis, Martin Vézina, Zhigang Wang | ||
| 38 | Rotational barriers in the peripheral benzodiazepine receptor ligand, PK 11195: Determination by quantum chemistry and NMR Victor W. Pike, Emmanuelle Briard, Fabrice G. Siméon, H. Umesha Shetty, Yong-Sok Lee | ||
| 39 | Aminopyrimidines as neuroprotective agents Tina Morgan Ross, Robert Zivin, Paul Burnett, Malcolm K. Scott, Elfrida Grant, Douglas E. Brenneman, Allen B. Reitz | ||
| 40 | Excitatory amino acid transporters (EAATs): II. Identification of potent and selective EAAT-2 inhibitors Alexander Greenfield, Cristina Grosanu, John Dunlop, Beal McIlvain, Tikva Carrick, Brian Jow, Qiang Lu, Dianne Kowal, Kristi Fan, John P Williams, John A. Butera | ||
| 41 | Excitatory amino acid transporters (EAATs): I. The search for selective EAAT modulators John A. Butera, Alexander Greenfield, Cristina Grosanu, John Dunlop, H. Beal McIlvain, Tikva Carrick, Brian Jow, Qiang Lu, Dianne Kowal, John P Williams | ||
| 42 | Discovery and SAR of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety Michael G. N. Russell, Robert W. Carling, Leslie J. Street, Richard T. Lewis, Andrew Mitchinson, Andrew S. R. Jennings, Melissa Hinch, John R. Atack, Susan M. Cook, Frances Bromidge, Keith A. Wafford, George R. Marshall, David S. Reynolds, Joanna Stanley, Rachael Lincoln, Spencer Tye, Wayne Sheppard, Bindi Sohal, Andrew Pike, Maria Dominguez, José L. Castro | ||
| 43 | Neuroprotective effects of EGIS-11229, a 2,3-benzodiazepine type AMPA antagonist József Barkóczy, István Ling, Gyula Simig, Gábor Gigler, Annamária Simó, Angela Benedek, Krisztina Móricz, Márta Ágoston, Miklós Végh, Gábor Kapus, Szabolcs Kertész, György Lévay, László Hársing, Gábor Szénási | ||
| 44 | Derivatives to improve the oral bioavailability and subsequent plasma and brain levels of [2-(8,9-dioxo-2,6-diaza-bicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]-phosphonic acid (EAA-090, perzinfotel), a competitive NMDA antagonist Reinhardt B. Baudy, John A. Butera, Jean Sze, Hong Chen, Uday Jain, Matthew Hoffmann, Michael K. May, Michael R. Brandt | ||
| 45 | Pharmacokinetic and pharmacodyamic effects of an oxymethylene-spaced diphenylester derivative of perzinfotel (EAA-090: [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid) in inflammatory and neuropathic pain models Reinhardt B. Baudy, Hong Chen, Uday Jain, Christine Huselton, Cheryl Mugford, Rana Ramdass, Hamza Kandoussi, Michael R. Brandt, Jeffrey D. Kennedy | ||
| 46 | Synthesis and discovery 3-amino piperidine and pyrolidine-based inhibitors of neurotransmitter re-uptake transporters Manuel Cases, John J. Masters, Louise Haughton, Gordon Campbell, Teresa Mann, Helene Rudyk, Magnus W. Walter, Graham Timms, Jeremy Gilmore, David R. Dobson, Craig White, John R. Boot, Jeremy D. Findlay, Lorna Hayhurst, Ann Helene Kluge, Sivi Mahadevan, Francoise J. Brunelle, Claude L. Delatour, Annie A. Lavis, Kenneth W. Perry, Frank P. Bymaster, Linda Thompson, Susan Hemrick-Luecke | ||
| 47 | Discovery of novel (2,4,5)-trisubstituted asymmetric pyran derivatives exhibiting selective affinity for the norepinephrine transporter: Importance of regioselectivity and stereoselectivity in binding activity, Part-I Shijun Zhang, Juan Zhen, Maarten Reith, Aloke Dutta | ||
| 48 | Further structural exploration of novel (2,4,5)-trisubstituted asymmetric pyran derivatives: Exploration of different N-benzyl substitutions on activity for monoamine transporters, Part-II Shijun Zhang, Fernando Fernandez, Juan Zhen, Maarten Reith, Aloke Dutta | ||
| 49 | Synthesis of an easily 18F-labeled and high affinity candidate radioligand for PET imaging of brain mGluR5 receptors Fabrice G. Siméon, Velvet M. Patterson, Frederick T. Chin, Robert B. Innis, Victor W. Pike | ||
| 50 | Discovery and biological profile of a new class of metabotropic receptor 1 allosteric antagonist Satoru Itoh, Atsushi Satoh, Yasushi Nagatomi, Yukari Hirata, Gentaroh Suzuki, Toshifumi Kimura, Akio Satow, Mikiko Hata, Hiroshi Kawamoto, Hisashi Ohta | ||
| 51 | Design and synthesis of novel mGluR5 antagonists Santosh S Kulkarni, Barbara Nightingale, Christina M. Dersch, Richard B. Rothman, Amy Hauck Newman | ||
| 52 | Pyridazinone derived phenylalanine amides as alpha4 integrin antagonists Yong Gong, Joseph K. Barbay, Alexey B. Dyatkin, Tamara A. Miskowski, Edward S. Kimball, Stephen M. Prouty, M. Carolyn Fisher, Rosemary Santulli, Craig R. Schneider, Nathaniel H. Wallace, John A. Masucci, William E. Hageman, Scott Ballentine, Dennis J. Hlasta, Pamela J. Hornby, Wei He | ||
| 53 | N-Ureido and N-carbamido pyridazinone-functionalized phenylalanines as alpha4beta7 integrin antagonists Joseph K. Barbay, Yong Gong, Alexey B. Dyatkin, Tamara A. Miskowski, Edward S. Kimball, Stephen M. Prouty, M. Carolyn Fisher, Rosemary Santulli, Craig R. Schneider, Nathaniel H. Wallace, William E. Hageman, John A. Masucci, Scott Ballentine, Dennis J. Hlasta, Pamela J. Hornby, Wei He | ||
| 54 | Synthesis and biological studies of an integrin alpha-v-beta,5 guided therapeutic Amir P. Tamiz, David C. Griffith, Teresa Aja, Lingna Li, Fang Liao, Krishnan Subbiah, Michael Whiney, Miriah Leclerc, Curt Bradshaw, Rodney Lappe, Sanjib Das, Subhash C. Sinha, Carlos F. Barbas III | ||
| 55 | Novel bivalent integrin antagonist compounds Anand Francis, Christopher A. Burnett, Zhimin Shen, King C. P. Li, Narasimhan Danthi | ||
| 56 | Phenylalanine amide derivatives as alpha4 integrin antagonists Tamara A. Miskowski, Alexey B. Dyatkin, Yong Gong, Joseph K. Barbay, M. Carolyn Fisher, Edward S. Kimball, Rosemary Santulli, Craig R. Schneider, Nathaniel H. Wallace, Scott Ballentine, Dennis J. Hlasta, Pamela J. Hornby, Wei He | ||
| 57 | Novel small-molecule antagonists of the chemokine receptor CXCR3 Marc-Raleigh Brescia, Andrew G. Cole, Ilana L. Stroke, Christopher Haskell, Sofia Ribeiro, Srilatha Simhadri, Joan J. Zhang, Zahid Hussain, Kenneth C. Appell, Ian Henderson, Maria L. Webb | ||
| 58 | Discovery and optimization of 2-aminothiazole derivatives as CCR4 antagonists Xuemei Wang, Feng Xu, Qingge Xu, Hossen Mahmud, Jonathan Houze, Liusheng Zhu, Michelle Akerman, George Tonn, Liang Tang, Daniel J. Dairaghi, Tassie L. Collins, Julio C. Medina | ||
| 59 | Design, synthesis and structure-activity relationship studies of novel 4,4-disubstituted piperidine based CCR5 antagonists as anti-HIV-1 agents Jennifer Peckham, Donald Anderson, Chris Aquino, Neil Bifulco, Larry Boone, Pek Chong, Maosheng Duan, Robert Ferris, Wieslaw Kazmierski, Terry Kenakin, Daniel G Lang, Ed McLean, Angilique Svolto, Patricia Wheelan, Michael Youngman | ||
| 60 | Mechanistic studies of novel voltage-gated sodium channel blockers as inhibitors of prostate cancer Todd P. Hansen, Jill E. Lynch, Manoj K. Patel, Paulianda J. Griffith, Robert A. Sikes, Milton L. Brown | ||
| 61 | Chemical evolution of tricyclic antidepressants into novel monocyclic amines with potent sodium channel activity Debjani P. Hudgens, Milton L. Brown, Cathy Taylor, Manoj K. Patel | ||
| 62 | Disjunctive approaches towards new steroidal sodium channel blockers based on a cholic acid scaffold Gary C. Davis, Paulianda J. Griffith, Timothy Batts, Manoj Patel, Milton L. Brown | ||
| 63 | Comparative molecular field analysis and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore Yuesheng Wang, Paulianda J. Griffith, James D. Anderson, Paul W Lenkowski, Victoria K. Landry, Manoj K Patel, Seong-Hoon Ko, Milton L. Brown | ||
| 64 | Identification and characterization of small molecule modulators of KChIP/Kv4 function Lynne P. Greenblatt, Mark Bowlby, Pranab Chanda, Wade Edris, Joe Hinson, Flora Jow, Alan Katz, Girija Krishnamurthy, Keith Pitts, Kevin Ryan, Howard Zhang | ||
| 65 | Structure-activity relationship studies on diaminopyrimidines as growth hormone secretagogue receptor (GHS-R) antagonists Bo Liu, Gang Liu, Mei Liu, Zhili Xin, Hongyu Zhao, Michael D. Serby, Christi Kosogof, Lissa TJ. Nelson, Bruce G. Szczepankiewicz, Wiweka Kaszubska, Verlyn G. Schaefer, Douglas H. Falls, Christine A. Collins, Hing L. Sham | ||
| 66 | Discovery of potent, selective and orally bioavailable growth hormone secretagogue receptor (Ghs-R) antagonists Zhili Xin, Michael D. Serby, Hongyu Zhao, Mei Liu, Bo Liu, Charles W Hutchins, Kathy Sarris, Hoff Ethan, Douglas H Falls, Christine A. Collins, Chunwei Lin, Christopher A Ogiela, Michael E. Brune, Gene Bush, Brian Droz, Tom Fey, Vicki Knourek-Segel, Robin Shapiro, Peer Jacobson, David Beno, Teresa Turner, Hing L. Sham, Gang Liu | ||
| 67 | Diaminopyrimidines as growth hormone secretagogue receptor antagonists Michael D. Serby, Gang Liu, Hongyu Zhao, Bruce G. Szczepankiewicz, Christi Kosogof, Wiweka Kaszubska, Douglas H. Falls, Verlyn G. Schaefer, Eugene N. Bush, Robin Shapiro, Brian A. Droz, Victoria E. Knourek-Segel, Thomas A. Fey, Michael E. Brune, David Beno, Teresa Turner, Christine A. Collins, Peer B Jacobson, Hing L. Sham | ||
| 68 | A-784168, a novel TRPV1 receptor antagonist as analgesic agent Brian S. Brown, Guo Zhu Zheng, Robert G. Schmidt, Ryan G. Keddy, John R. Koenig, Tammie K Jinkerson, Heath A. McDonald, Minglei Cui, Prisca Honore, Kennan C. Marsh, John F. Darbyshire, Carol S. Surowy, Robert Moreland, Michael Jarvis, Connie R. Faltynek, Chih-Hung Lee | ||
| 69 | Novel, potent TRPV1 receptor antagonists Brian S. Brown, Ryan G. Keddy, Guo Zhu Zheng, Robert G. Schmidt, John R. Koenig, Prisca Honore, Michael F. Jarvis, Carol S. Surowy, Connie R. Faltynek, Chih-Hung Lee | ||
| 70 | SAR of a new series of indole and indazole ureas as TRPV1 antagonists Irene Drizin, Arthur Gomtsyan, Erol K. Bayburt, Richard J. Perner, Stanley Didomenico, John R. Koenig, Heath A. McDonald, Prisca Honore, Carol T. Wismer, Kennan Marsh, Jill Wetter, Michael F. Jarvis, Connie R. Faltynek, Chih-Hung Lee | ||
| 71 | 4-(Pyridin-2-yl)-piperazine-N-cyano-1-carboxamidine analogs as vanilloid receptor 1 antagonists Xiaoming Zhou, Qun Sun, Chongwu Zhang, Kenneth J. Valenzano, Jinchen Huang, Kevin C. Brown, Donald J. Kyle | ||
| 72 | Comparative protein structure modeling of the human Angiotensin II Type 1 (AT-1) receptor: Insights into the molecular determinants of the AT-1-ligand interactions Akshay Patny, Prashant V. Desai, Mitchell A. Avery | ||
| 73 | N6-Ethyl-2-alkynyl adenosine derivatives as a selective human A3 adenosine receptor agonist Ran Zhu, Cynthia R. Frazier, Timothy L. Macdonald, Joel Linden | ||
| 74 | Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as human A3 adenosine receptor agonists Lak Shin Jeong, Hyuk Woo Lee, Zhan-Guo Gao, Kenneth A. Jacobson, Dae Hong Shin, Jeong A Lee, Ae Yil Kim | ||
| 75 | Design, synthesis, and biological evaluation of novel adenosine A2A receptor antagonists Lisa S. Silverman, John Caldwell, William J. Greenlee, Eugenia Y. Kiselgof, Julius Matasi, Deen Tulshian, Leyla Arik, Carolyn Foster | ||
| 76 | Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists Unmesh Shah, Craig D. Boyle, Samuel Chackalamannil, Bernard Neustadt, Carolyn Foster, Leyla Arik, Ying Zhai, Jean E. Lachowicz, Kwokei Ng, Shiyong Wang, Angela Monopoli, Ennio Ongini | ||
| 77 | (-)-Mefloquine as a starting point for the discovery of selective adenosine A2A receptor antagonists Allan M. Jordan, Karen Benwell, Ian A. Cliffe, Colin T. Dourish, Paul R. Giles, Roger J. Gillespie, Tony R. Knight, Joanne Lerpiniere, A. Misra, Simon E. Ward, Scott M. Weiss | ||
| 78 | Human P2Y6 receptor: Molecular modeling and structure-based drug design Stefano Costanzi, Pedro Besada, Bhalchandra V. Joshi, Savitri Maddileti, Liaman Mamedova, Dae Hong Shin, Maria J Gonzalez-Moa, Victor E. Marquez, T. Kendall Harden, Kenneth Jacobson | ||
| 79 | Synthesis and SAR of novel thieno[3,2-d]pyrimidine derivatives as selective antagonists of the adenosine A2A receptor Allan M. Jordan, Ian A. Cliffe, Claire E. Dawson, Colin T. Dourish, Paul R. Giles, Roger J. Gillespie, Tony R. Knight, Anthony Lawrence, Joanne Lerpiniere, A. Misra, Robert M. Pratt, Richard S. Todd, Rebecca Upton, Scott M. Weiss | ||
| 80 | Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator Justin J. Heynekamp, Lucy A. Hunsaker, Lorraine M. Deck, David L. Vander Jagt | ||
| 81 | Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor Yong-Chul Kim, Jung-Sun Lee, Katrin Sak, Frederic Marteau, Liaman Mamedova, Jean-Marie Boeynaems, Kenneth A. Jacobson | ||
| 82 | Optimization of privileged structure for selective and potent melanocortin subtype-4 receptor ligands Qingmei Hong, Raman K. Bakshi, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, David H. Weinberg, Lex H. T. Van der Ploeg, Arther A. Patchett, Ravi Nargund | ||
| 83 | SAR and pharmocology of potent and selective melanocortin subtype-4 receptor agonists with azabicyclo carboxamide moiety Liangqin Guo, Zhixiong Ye, Khaled J. Barakat, Patrick G. Pollard, Brenda L. Palucki, Iyassu K. Sebhat, Raman K. Bakshi, Rui Tang, Rubana N. Kalyani, Aurawan Vongs, Charles I. Rosenblum, Tanya MacNeil, David H. Weinberg, Qianping Peng, Constantin Tamvakopoulos, Randy R. Miller, Ralph A. Stearns, Erin McGowan, William J. Martin, Airu S. Chen, Joseph M. Metzger, Howard Y. Chen, Alison M. Strack, Euan MacIntyre, Lex H. T. Van der Ploeg, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 84 | 2-Aminoquinoline MCH1R antagonists: Structure-activity determinants and binding mode investigations Trond Ulven, Thomas M. Frimurer, Jean-Marie Receveur, Paul Brian Little, Řystein Rist, Pia K. Nřrregaard, Thomas Högberg | ||
| 85 | 4-Oxo-4H-chromene-2-carboxamides as melanin concentrating hormone antagonists: Structure-activity relationship of antiobesity therapeutics Jennifer C. Freeman, John K. Lynch, Mathew M. Mulhern, Andrew S. Judd, Rajesh R. Iyengar, Gang Zhao, Sevan Brodjian, Doug Falls, Brian D. Dayton, Christopher A. Ogiela, Hanna E. Sidorowicz, Robin Shapiro, Victoria Knourek-Segel, Michael Brune, Sandra T. Leitza, Gilbert J. Diaz, Hing L. Sham, Christine A. Collins, Philip R. Kym | ||
| 86 | Discovery, lead optimization and in vivo studies on coumarin-based small molecule MCHr-1 antagonists Rajesh R. Iyengar, Andrew J. Souers, John K. Lynch, Andrew S. Judd, Ju Gao, Jennifer C. Freeman, Mathew Mulhern, Anil Vasudevan, Dariusz Wodka, Christopher Blackburn, James Brown, Jennifer Lee Che, Courtney A. Luchaco-Cullis, Sujen Lai, Matthew J. Lamarche, Thomas H. Marsilje, Jonathan B. Roses, Bradley Geddes, Michael A. Patane, Dennis G. Fry, Brian D. Dayton, Sevan Brodjian, Doug H. Falls, Michael E. Brune, Eugene N. Bush, Robin Shapiro, Victoria E. Knourek-Segel, Thomas A. Fey, Cathleen A. McDowell, Thomas B. Farb, Glenn A. Reinhart, Lee C. Preusser, Kennan C. Marsh, Lisa E. Hernandez, James M. Schmidt, Hing L. Sham, Christine A. Collins, Philip R. Kym | ||
| 87 | Identification and SAR of hERG selective Melanin-concentrating hormone receptor 1 antagonists Mathew M. Mulhern, Andrew Judd, Jennifer Freeman, John Lynch, Rajesh Iyengar, Andrew J. Souers, Ju Gao, Gang Zhao, Dariusz Wodka, Gilbert Diaz, Ruth Martin, Sevan Brodjian, Doug Falls, Brian Dayton, Hing L. Sham, Christine A. Collins, Philip R. Kym | ||
| 88 | Synthesis and structure activity relationship of biaryl cannabinoid mimetics: Phenol replacements Q. Jean Zhou, Karin Worm, Roland E. Dolle, Gabriel Stabley, Robert N. DeHaven | ||
| 89 | Paper Withdrawn | ||
| 90 | Synthesis and biological evaluation of novel pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists Hans G. F. Richter, D. R. Adams, A. Benardeau, M. J. Bickerdike, J. M. Bentley, T. J. Blench, I. A. Cliffe, J. E. P. Davidson, C. Dourish, P. Hebeisen, G. A. Kennett, A. R. Knight, C. S. Malcolm, P. Mattei, A. Misra, J. Mizrahi, N. J. T. Monck, J-M. Plancher, S. Roever, J. R. A. Roffey, S. Taylor, S. P. Vickers | ||
| 91 | Development of dual-acting benzofurans and benzomorpholines as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists Michihiro Ohno, Takahiro Takeda, Yoichiro Tanaka, Kei Makita, Mitsuko Miyamoto, Naohiro Yamada, Atsushi Ohtake | ||
| 92 | Pyrimidine substituted 2-phenyl-4-piperazinylbenzimidazole inhibitors of Gonadotropin Releasing Hormone John F. Mehlmann, Jeffrey C. Pelletier, Joseph T. Lundquist IV, Joshua E. Cottom, Linda Shanno, Murty V. Chengalvala, Irene B. Feingold | ||
| 93 | Synthesis of 4’-carboxamido N-Boc-2’,6’-dimethyl-L-phenylalanines as surrogates for DMT in opioid receptor ligands Chaozhong Cai, Henry J. Breslin, Tamara A. Miskowski, Sui-Po Zhang, Pamela Hornby, Wei He | ||
| 94 | Synthesis and SAR studies for 3,4-disubstituted oxyindoles as potent and selective antagonists of the EP3 receptor for PGE2 J Singh, N. Zhou, G Hategan, W Zeller, Lei Zhao, P Yu, L Enache, J Zhang, E Onua, J Ramirez, G Palsdottir, G Halldorsdottir, T Andersson, M Gurney | ||
| 95 | Synthesis, biological evaluation and metabolic stability of 3,4-disubstituted indoles as potent and selective EP3 receptor antagonists J Singh, N Zhou, G Hategan, W Zeller, A Polozov, M Goldsmith, M Krohn, H Anderson, R Mishra, J Zhang, E Onua, J Ramirez, G Palsdottir, G Halldorsdottir, T Andresson, M Gurney | ||
| 96 | Discovery of novel aza-prostaglandin derivatives analogs of PGE2 as selective EP2 and EP4 receptors agonists Gian Luca Araldi, Nadia Brugger, Bagna Bao, David Fischer, Srinivasa Karra, Sean McKenna, Yufang Xiao, Zhong Zhao | ||
| 97 | Structure-based design of a class of potent small molecule inhibitors of Bcl-2 and Bcl-xL proteins Guozhi Tang, Zaneta Nikolovska-Coleska, Renxiao Wang, Jie Guo, Mei Lan Liu, Su Qiu, York Tomita, Shaomeng Wang | ||
| 98 | Discovery of novel orally active and selective ureido-NPY Y5 antagonists Guoqing Li, Ying Huang, Joseph Kelly, Andrew Stamford, William Greenlee, Deborra Mullins, Mario Guzzi, Xiang Zhang, Joyce J. Hwa, Jun Gao, Lorraine Ghibaudi, Sam Weihaus, K-C. Cheng | ||
| 99 | Benzodiazepines as selective bradykinin B2 receptor antagonists Carmen Leung, V. Santhakumar, Mirek Tomaszewski, Christopher Walpole, Simon Woo, Lynda Adam, Joanne Butterworth, Claude Godbout, Kemal Payza, Marie Roumi | ||
| 100 | Potent and selective BK-1 antagonists – 4-substituted phenyl cyclohexanes John J. Lim, M. Kristine Markowitz, K.L. Murphy, S.S. O'Malley, R. W. Ransom, Ray S. Chang, D.J. Pettibone, R.M. Freidinger, M. G. Bock, D.S. Su | ||
| 101 | SAR of pyrrolidine containing H3 antagonists: Trends across multiple chemical series Diana L Nersesian, Lawrence A Black, Thomas R Miller, Timothy A Esbenshade, Arthur A Hancock, Marlon D Cowart | ||
| 102 | Bicyclic heteroaromatic histamine H3 antagonists: Synthesis, potency, and in vivo profiles of analogs optimized for drug-likeness Robert J. Altenbach, Huaqing Liu, Timothy A. Esbenshade, Gerard B. Fox, Arthur A Hancock, Marlon Cowart | ||
| 103 | Design, synthesis, and structure-activity relationship of novel non-imidazole histamine H3 antagonists Huaqing Liu, Robert J. Altenbach, Thomas R. Miller, Timothy A. Esbenshade, Arthur A Hancock, Marlon Cowart | ||
| 104 | Discovery of novel natural alkaloid conessine as potent histamine H3 receptor antagonist Chen Zhao, Y. L. Bennani, S. Gopalakrishnan, M. Sun, Timothy A. Esbenshade, K. M. Krueger, T. R. Miller, D. G. Witte, Kennan C. Marsh, Marlon D. Cowart, A. A. Hancock | ||
| 105 | Synthesis and pharmacological evaluation of selective, potent delta opioid agonists as novel analgesics Andrea Penwell, Andrew Griffin, Paul Jones, Sylvain Bernard, Carmen Leung, Simon Woo, William Brown, Christopher Walpole, Maryse Labarre, Martin Coupal, Stéphane St-Onge, Lejla Hodzic, Dominic Salois, Kemal Payza | ||
| 106 | Rationale and synthesis of potent dual δ/μ opioid receptor ligands for motility disorders Henry J. Breslin, Tamara A. Miskowski, Chaozhong Cai, Santosh V. Coutinho, Sui-Po Zhang, Pamela J. Hornby, Wei He | ||
| 107 | Synthesis and structure activity relationship of a series of 2- and 6-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists Allan J. Goodman, Bertrand Le Bourdonnec, Mathieu Michaut, Hai Fen Ye, Thomas M. Graczyk, Serge Belanger, Robert N. DeHaven, Roland E. Dolle | ||
| 108 | Design, synthesis and biological evaluation of mu opioid selective biaryl-substitiuted 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one derivatives Alfonzo D. Jordan, Michael J. Orsini, Steven A. Middleton, Peter J. Connolly, Douglas E. Brenneman, Kevin Pan, Allen B. Reitz | ||
| 109 | Synthesis and evaluation of the benz[f]indene neurosteroid analogues Jamie B Scaglione, Brad D. Manion, Alex S. Evers, Steven Mennerick, Charles F. Zorumski, Douglas F. Covey | ||
| 110 | NK1 Antagonists based on seven membered lactam scaffolds Jason M Elliott, Emma J Carlson, Gary G. Chicchi, Olivier Dirat, Maria Dominguez, Ute Gerhard, Richard Jelley, A. Brian Jones, Marc M Kurtz, Kwei-lan Tsao, Alan Wheeldon | ||
| 111 | Design and synthesis of thrombin receptor antagonists Martin Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William J. Greenlee, Grace Kao, Yan Lin, Hsingan Tsai, Yan Xia, Jacqueline Agans-Fantuzzi, Ho-Sam Ahn, George Boykow, Matthew Bryant, Madhu Chintala, Carolyn Foster, Janice Lau | ||
| 112 | Paper Withdrawn | ||
| 113 | Design and synthesis of arylsulfonyl thioureas as novel potent cyclophilin ligands Larisa E. Serdyuk, Douglas E. Wilkinson, Sean K. Hamilton, Sergei A. Belyakov, Ling Wei, Bert E. Thomas IV, Gregory S. Hamilton, Edmond Massuda, Marigo Stathis, Mike Fuller, Camilo J. Rojas, Joseph P. Steiner, Shirley Huang, George Liu, Yong-Qian Wu | ||
| 114 | Design and synthesis of arylsulfonylthiosemicarbazides as potent, nonpeptidic cyclophilin inhibitors Yong-Qian Wu, Douglas E. Wilkinson, Gregory S. Hamilton, Joseph Steiner, Sean Hamilton, Bert E. Thomas IV, Edmond Massuda, Mike Fuller, Marigo Stathis, Sergei A. Belyakov | ||
| 115 | Novel 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists Hassan Elokdah, Albert J. Robichaud, David Z. Li, Geraldine R. McFarlane, Ronald C. Bernotas, Gregory J. Tawa, Guo Ming Zhang, Deborah L. Smith, Lee E. Schechter | ||
| 116 | Novel 1-(2-aminoethyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists Ronald C. Bernotas, Steven Lenicek, Schuyler A. Antane, Guo Ming Zhang, Deborah L. Smith, Joseph Coupet, Lee E. Schechter | ||
| 117 | 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines as novel 5-HT6 receptor ligands Ronald C. Bernotas, Schuyler A. Antane, Steven Lenicek, Simon N. Haydar, Albert J. Robichaud, Guo Ming Zhang, Deborah L. Smith, Joseph Coupet, Lee E. Schechter | ||
| 118 | Spirocyclic indanes as ligands for the NOP (ORL-1) receptor R. Richard Goehring, Xiaoming Zhou, Jin-Cheng Huang, Lisa J. Barnett, Qun Sun, Sam F. Victory, Kenneth J. Valenzano, Wendy S. Miller, Shen Shan, Donald J. Kyle | ||
| 119 | Development of predictive CoMFA and CoMSIA models for alkoxylated and hydroxylated chalcones as anti-malarial agents Devendra Puntambekar, Mange Ram Yadav, Rajani Giridhar | ||
| 120 | A novel one-pot synthesis of thalidomide and its derivatives under microwave irradiation Ellis Benjamin, Yousef Hijji | ||
| 122 | Design and synthesis of novel indole deivatives as anti-angiogenic agents Sureyya Olgen, Dogu Nebioglu, Eiichi Akaho | ||
| 121 | Synthesis of radiolabeled 5-(aminomethyl)-2l-aminopyrrolo[2,3-d]pyrimidine-4(3H)-one (preQ1) and 2-amino-5-[(1S, 2R, 3S)-2, 3-dihydroxycyclopent-4-enylamino-methyl]pyrrolo[2, 3-d]pyrimidine-4(3H)-one (queuine) Sureyya Olgen, George A. Garcia | ||
| 123 | Lipophilicity coefficients of new potential PET dopamine D2 and D3 receptor ligands (E)-4, 3, 2-[11C]methoxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cinnamoylamides and (E)-4, 3, 2-[18F]fluoro-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cinnamoylamides Mingzhang Gao, Ji-Quan Wang, Qi-Huang Zheng | ||
| 124 | Synthesis of carbon-11 and fluorine-18 labeled 2-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline analogues as new potential PET AMPA receptor ligands Mingzhang Gao, Ji-Quan Wang, Qi-Huang Zheng | ||
| 125 | Development of [11C]MPT as a potential agonist PET tracer for 5-HT1A receptor imaging Vattoly J Majo, Ramin V. Parsey, Hadassah Tamir, Matthew Millak, Shu-Chi Hsiung, Jaya Prabhakaran, Norman R. Simpson, Julie Arcement, Ronald L. Van Heertum, J. John Mann, J. S. Dileep Kumar | ||
| 126 | Synthesis and in vivo evaluation of [11C]MPM as a 5-HT2A receptor PET ligand Jaya Prabhakaran, Ramin V. Parsey, Vattoly J Majo, Norman R. Simpson, Julie Arcement, Ronald L. Van Heertum, J. John Mann, J. S. Dileep Kumar | ||
| 127 | Synthesis of an iodine-123 labeled rofecoxib analogue: A potential SPECT agent George W. Kabalka, Arjun R. Mereddy, Brandy Belue, Hildegard Schuller | ||
| 128 | Biotin derivatives for radiotherapeutics and fluorescent in vivo models Shelly James, Kevin Maresca, John Valliant, John W. Babich, Laurie Doering, Jon Zubieta | ||
| 129 | Efficient deuterium labeling method of biologically active compounds Hiroyoshi Esaki, Fumiyo Aoki, Tomohiro Maegawa, Hironao Sajiki, Kosaku Hirota | ||
| 130 | Facile and efficient isotope labeling method for phenylalanine derivatives catalyzed by Pd/C Tomohiro Maegawa, Akira Akashi, Hiroyoshi Esaki, Fumiyo Aoki, Hironao Sajiki, Kosaku Hirota, Kenjiro Tatematsu, Yukio Mori | ||
| 131 | New effective tool for selecting optimal catalytic technology for chemical transformations Johannes G. Donkervoort, James A. Schwindeman | ||
| 132 | Scale up synthesis of resolvin E1 and its bioaction Tomomichi Chonan, Makoto Arita, Kiyoshi Takayama, Charles N. Serhan | ||
| 133 | Investigation of method evaluating the activities of SOD-like antioxidants using the whole synthesis-typed ROS sensor Makoto Yuasa, Kenichi Oyaizu, Aritomo Yamaguchi, Seiko Ohseki, Tomohiro Kobayashi, Yuujiro Toyoda, Satoshi Tsutsui, Masahiro Nanba | ||
| 134 | Paper Withdrawn | ||
| 135 | Evaporative light scattering and polymeric SPE: A combined approach for compound repository analysis and clean up Aubrey J Mendonca, Paul A Boguszewski, A F Coffey, John W Davies, A A MacDonald, F P Warner | ||
| 136 | Solid phase extraction of metals: Facile removal of active metal species prior to compound screening Aubrey J Mendonca, Paul A Boguszewski, Andrew F Coffey, John W Davies, Alasdair A MacDonald, Frank P Warner | ||
| 137 | One-step scaffold hopping with novel synthetic strategies László Ürge, Ákos Papp, Richard Jones, Norbert Varga, Ferenc Darvas | ||
| 138 | Diversity oriented synthesis(DOS) using poly-functional scaffolds Eleanor F. Duffy, Mauro F. A. Adamo | ||
| 139 | Paper Withdrawn | ||
| 140 | Crystallization of pharmaceuticals on self-assembled monolayers on gold Kasim Biyikli, Branko Zugic, Garrett P. Ebersole, Joshua B. Allor, John C. MacDonald | ||
| 141 | Nucleation and growth of polymorphs of pharmaceuticals on bulk substrates and in microfluidic channels with chemically modified surfaces John C. MacDonald, Kasim Biyikli, Branko Zugic, Garrett P. Ebersole, Joshua B. Allor | ||
| 142 | Natural products analysis by new continuous polarity/volume gradient TLC Yi-bo Guo, Qi-Feng Ma | ||
| 143 | Structural characterization and molecular investigation of a serendipitously discovered bioactive macromolecule, lignin sulfate Arjun Raghuraman, Jay N. Thakkar, Gunnar Thor Gunnarsson, Michael Hindle, Umesh R. Desai | ||
| 144 | The role of planar chromatography in column purification Jack Liu | ||
| 145 | The application of evaporative light scattering detection to high throughput HPLC methods John A. McConville, S M Bullock | ||
| 146 | A protocol to accomplish "Homo-Robinson" annulation: Application to the guanacastepene problem Heedong Yun, Samuel J. Danishefsky | ||
| 147 | Plusbacin A3: Efforts towards the solution phase synthesis Aaron Wohlrab, Ryan Lamer, Michael S. VanNieuwenhze | ||
| 148 | Synthetic studies toward Nogalamycin Ryan B. Lamer, Luis R. Rivera, Tristan Beaudette, Michelle Tetalman, Michael S. VanNieuwenhze | ||
| 149 | Synthesis of enone analogues of the natural product curcumin Waylon M. Weber, Lucy A. Hunsaker, Lorraine M. Deck, David L. Vander Jagt | ||
| 150 | Synthesis and stereochemistry of epiquinamide Richard W. Fitch, Gordon D. Sturgeon | ||
| 151 | A concise total synthesis of bromopyrrole alkaloid Manzacidin A Hongfeng Chen, James C. Lanter, Xuqing Zhang, Zhihua Sui | ||
| 152 | A total synthesis of (-)-treprostinil using stereoselective Pauson Khand reaction Kuanquiang Gao, Robert M. Moriarty, Jeffrey R. Deschamps | ||
| 153 | Synthesis of Sansalvamide A derivates Joseph D. Brown, Ahmet Kekec, Shelli McAlpine | ||
| 154 | Studies towards the biomimetic synthesis of pyridomacrolidin Nageswara R Irlapati, Jack E Baldwin, Robert M Adlington | ||
| 155 | Solvent-free synthesis of novel dihydropyrimidinones scaffolds Qiang Yu, Fengping Wei, Liangfu Huang, Zhiqiang Fang, Wuping Ma | ||
| 156 | Recent progress on the synthesis and chemical-biological properties of nucleoside boranophosphate analogues Ping Li, Mikhail I. Dobrikov, Hongyan Liu, Charlotta K. Wennefors, Barbara R. Shaw | ||
| 157 | Synthesis of ribo- and deoxyribonucleoside α-P-borano- and α-P-thiodiphosphates by a phosphoramidite approach Zhihong Xu, Barbara Ramsay Shaw | ||
| 158 | Enantioselective carbolithiation cascade reaction for indole synthesis Anne-Marie L. Hogan, Donal F. O'Shea | ||
| 159 | Synthesis of new GMII inhibitors, diversity-oriented 5-substituted swainsonine analogues, via stereoselective Mannich reaction Shinichi Nakayama, Hideko Nagasawa, Tomoya Fujita, Toshihiro Hashimoto, Yoshinori Asakawa, Yoshihiro Uto, Hitoshi Hori, Douglas A. Kuntz | ||
| 160 | Development of efficient synthetic methods for chiral cyclopentenol derivatives using ring-closing metathesis (RCM) reaction and synthesis of unnatural neplanocin A (NPA) analogues Jong-Hyun Cho, Chung K. Chu | ||
| 161 | Paper Withdrawn | ||
| 162 | Enantioselective synthesis of 2-substituted pipecolic acids and its application Duen-ren Hou, Shin-Yi Hung, Chung-Cheng Hu | ||
| 163 | Synthesis and opioid binding affinity of (-)-octahydro-1H-benzofuro[3,2-e]isoquinolines Ling-Wei Hsin, Li-Te Chang, C. M. Dersch, R. B. Rothman | ||
| 164 | Preparation and identification of pentostain isomers Liping Gao, Wuyi Wang, Meizheng Liu | ||
| 165 | Indole inhibitors of cPLA2α: Synthetic routes Richard Vargas, Katherine L. Lee, Mark L. Behnke, Lihren Chen, Wei Li, Paresh M. Thakker, Weiheng Wang, Fuk-Wah Sum, Alexander Oliphant, Kun Wu, Vishnu Hegde, Marina WH. Shen, John C. McKew | ||
| 166 | Carbocyclic N-3 isonucleosides as SAHase inhibitors for antiviral chemotherapeutics Brian A. Bakke, Sylvester L. Mosley, Joshua M. Sadler, Narsesh K. Sunkara, Katherine L. Seley | ||
| 167 | Seldi proteinchip array analysis of hepatitis B virus infection and hepatocellular carcinoma Rui Zhu, Qing-Yu He, Jen-Fu Chiu | ||
| 168 | Synthesis and in vitro anti-HCV screening of a series of ring-expanded ("fat") nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system Peng Zhang, Ramachandra S. Hosmane | ||
| 169 | m-Tyrosine- and tic-based macrocyclic inhibitors of Hepatitis C Virus (HCV) NS3 protease: Synthesis and biological activity Kevin X Chen, F. George Njoroge, John Pichardo, Andrew Prongay, Nancy Butkiewicz, Nanhua Yao, Vincent Madison, Viyyoor Girijavallabhan | ||
| 170 | Hepatitis C virus NS3 serine protease inhibitors: Discovery of potent P2’ moiety Ashok Arasappan, F. G. Njoroge, T-Y. Chan, F. Bennett, S. L. Bogen, K. Chen, H. Gu, L. Hong, E. Jao, Y-T. Liu, R. G. Lovey, T. Parekh, R. E. Pike, P. Pinto, B. Santhanam, Srikanth Venkatraman, H. Vaccaro, H. Wang, X. Yang, Z. Zhu, N. Patel, J. McCormick, Brian McKittrick, A. K. Saksena, V. Girijavallabhan, J. Pichardo, N. Butkiewicz, R. Ingram, B. Malcolm, A. Prongay, N. Yao, B. Marten, V. Madison, S. Kemp, O. Levy, M. Lim-Wilby, S. Tamura, A. K. Ganguly | ||
| 171 | Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3 serine protease inhibitors Ashok Arasappan, F. George Njoroge, Tejal N. Parekh, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Nanhua Yao, Viyyoor Girijavallabhan | ||
| 172 | P2 Diamino acid derivatives as hepatitis C virus NS3 serine protease inhibitors Ashok Arasappan, F. George Njoroge, Haining Gu, Tejal N. Parekh, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Nanhua Yao, Viyyoor Girijavallabhan | ||
| 173 | Application of phenylphosphate mimetics to the design and synthesis of olefin metathesis-derived Grb2 SH2 domain-binding macrocycles Terrence R Burke Jr., Sang Uk Kang, Won Jun Choi, Zhen-Dan Shi, Rajeshri Karki, Jason Phan, Karen M. Worthy, Lakshman Bindu, Marc C. Nicklaus, David S. Waugh, Robert J. Fisher | ||
| 174 | Design and synthesis of depeptidized P2-P4 biaryl macrocyclic inhibitors of hepatitis-C NS3-4A protease Srikanth Venkatraman, F. George Njoroge, Viyyoor Girijavallabhan, V. Madison, N. Yao, Andrew Prongay, Nancy Butkiewicz, John Pichardo | ||
| 175 | Discovery of SCH6: A new ketoamide inhibitor of the HCV NS3 serine protease Stephane Bogen, A. Arasappan, F. Bennett, T-Y. Chan, Kevin X Chen, S. Hendrata, L. Hong, H. Huang, Edwin Jao, Y-T. Liu, R. Lovey, J. McCormick, T. Parekh, R. E. Pike, Patrick Pinto, S. Ruan, B. Santhanam, S. Venkatraman, H. Vaccaro, B. Vibulbhan, H. Wang, Z. Zhu, Brian McKittrick, F. G. Njoroge, A. K. Saksena, V. Girijavallabhan, B. Baroudy, N. Butkiewicz, A. Hart, R. Liu, B. Malcolm, J. Pichardo, D. Standring, A. Prongay, N. Yao, V. Madison, S. Kemp, O. Levy, M. Lim-Wilby, S. Tamura, A. K. Ganguly | ||
| 176 | Synthesis and structure-activity relationship of P3-aza-peptidomimetic analogs as potential HCV NS3-4A protease inhibitors Peggy P. Huang, John T. Randolph, Charles A. Flentge, Larry L. Klein, Kevin Kurtz, Alex Konstantinidis, Warren M. Kati, Xiaolin Zhang, Vincent S. Stoll, Dale J. Kempf | ||
| 177 | Discovery of BMS-433771, a respiratory syncytial virus fusion inhibitor Ny Sin, Kuo-Long Yu, Keith Combrink, Brian Venables, Xiangdong Alan Wang, Hatice Belgin Gulgeze, Rita L. Civiello, Kathleen F. Kadow, Christopher Cianci, Junius Clark, Eugene Genovese, Stacey Voss, Lucinda Lamb, Ivette Medina, Zheng Yang, Lisa Zadjura, Stella Huang, Dedong Wu, Qi Gao, Mark Krystal, Nicholas A. Meanwell | ||
| 178 | Inhibitors of respiratory syncytial virus fusion: Optimization of the C-5 subsituent Xiangdong Alan Wang, Kuo-Long Yu, Kathleen F. Kadow, Christopher Cianci, Julia Roach, Mark Krystal, David R. Langley, Nicholas A. Meanwell | ||
| 179 | Isatin oximes as inhibitors of respiratory syncytial virus fusion Brian L. Venables, Kuo-Long Yu, Bradley C. Pearce, Yi Zhang, Keith Combrink, Jan Thuring, Xiangdong Alan Wang, Rita L. Civiello, Hatice Belgin Gulgeze, Eugene Genovese, Christopher Cianci, Kathleen F. Kadow, Stacey Voss, Lucinda Lamb, Ivette Medina, Junius M. Clark, Zheng Yang, Lisa Zadjura, Stella Huang, Mark Krystal, Nicholas A. Meanwell | ||
| 180 | Discovery of TAK-242, a novel inhibitor of TLR4-mediated cytokine production as an anti-sepsis agent Takashi Ichikawa, Masami Yamada, Masayuki Ii, Toru Yamano, Norikazu Tamura, Katsumi Itoh, Tomoyuki Kitazaki | ||
| 181 | New and improved 5,10-dihydrobenzo[b][1,8]napthyridine-N-oxides as the next generation NNRTI’s with better activity profiles against clinically relevant HIV-1 mutants Anurag S Srivastava, Christine M. Tarby, Barry M. Johnson, Bhakthavatchalam Rajagopal, Matthew Curry, Qiyan Lin, Haisheng Wang, Anthony J. Cocuzza, Donna M. Bilder, Robert J. McHugh, Mona Patel, Lee T. Bacheler, Sharon Diamond, Susan Jeffrey, Ronald M. Klabe, Beverly C. Cordova, Sena Garber, Kelly Logue, Susan Erickson-Viitanen, George L. Trainor, James D. Rodgers | ||
| 182 | Linear-response study on the binding affinity of non-nucleoside RT inhibitors with HIV-1 reverse transcriptase Guangyu Sun, Marc C Nicklaus | ||
| 183 | Discovery and synthesis of HIV integrase inhibitors: Dihydroxypyrimidine-4-carboxamides as novel potent and selective agents Paola Pace, M. Emilia Di Francesco, Odalys Gonzalez Paz, Daria J. Hazuda, Ralph Laufer, Emanuela Nizi, Alessia Petrocchi, Michael Rowley, W.A. Schleif, Kara A. Stillmock, Marc V. Witmer, Vincenzo Summa | ||
| 184 | Discovery and synthesis of HIV integrase inhibitors: Development of potent bioavailable N-methyl pyrimidones Cristina Gardelli, Emanuela Nizi, Marco Poma, Benedetta Crescenzi, Ester Muraglia, Paola Pace, Rita Scarpelli, Vincenzo Summa, Michael Rowley, Odalys Gonzalez Paz, Ralph Laufer, William A. Schleif, Kara A. Stillmock, Marc Witmer, Daria Hazuda | ||
| 185 | From dihydroxypyrimidine carboxylic acids to carboxamide HIV integrase inhibitors Alessia Petrocchi, Paola Pace, Daria J. Hazuda, William A. Schleif, Kara A. Stillmock, Marc V. Witmer, Victor G. Matassa, Vincenzo Summa | ||
| 186 | HIV-1 integrase inhibitory peptides: Cyclization, dimerization, tetramerization and peptide inhibitory potency Krzysztof Krajewski, Christophe Marchand, Yves Pommier, Peter P. Roller | ||
| 187 | Versatile synthesis of 2, 5A-Tat antisense chimeras for anti-HIV/AIDS Longhu Zhou, Edgar R. Civitello, Nidhi Gupta, Ross Molinaro, Robert H. Silverman, Paul F. Torrence | ||
| 188 | Sophorolipids: Microbial glycolipids with anti-HIV and sperm-immobilizing activities Vishal Shah, Gustavo F. Doncel, Abul Azim, Theodoros Seyoum, Kristin Eaton, Irina Zalenskaya, Rena Hagver, Richard Gross | ||
| 189 | HIV protease inhibitors with potential for once-daily dosing and reduced side effects David A. DeGoey, William J. Flosi, David J. Grampovnik, Charles A. Flentge, Larry L. Klein, Clinton M. Yeung, Tatyana Dekhtyar, Lynn Colletti, Jeffrey F. Waring, Rita Ciurlionis, Kennan C. Marsh, James M. Schmidt, Sue J. Swanson, Vincent Stoll, Mulugeta Mamo, Hongmei Mo, Warren M. Kati, Akhteruzzaman Molla, Dale J. Kempf | ||
| 190 | Understanding the monophosphorylation efficiency of nucleosides by deoxycytidine kinase (dCK) and their mechanism of anti-HIV activity by molecular modeling Vikas Yadav, Yunho Jin, Chung K. Chu | ||
| 191 | Reductive cleavage of 1,2,4,5-tetraoxane antimalarials Bogdan A Solaja, Natasa Terzic, Kirsten Smith, Dejan Opsenica, Philip L Smith, Wilbur K. Milhous | ||
| 192 | Comparison between antimalarial spiroadmantyl 1,2,4-trioxane and 1,2,4-trioxolane pairs: Important balance between chemical reactivity and steric enviroment of the peroxide bond Xiaofang Wang, Yuxiang Dong, Sergio Wittlin, Jonathan L. Vennerstrom | ||
| 193 | Strategies for the optimization of antimalarial 1,2,4-trioxolanes: From hydrophobic prototype OZ03 to drug candidate OZ277 Yuxiang Dong, Jonathan L. Vennerstrom | ||
| 194 | Identification of novel antileishmanial compounds through in silico pharmacophore development and database searching Dawn A. Delfín, Apurba K. Bhattacharjee, Karl A. Werbovetz | ||
| 195 | Paper Withdrawn | ||
| 196 | Investigation of ecFabI’s interaction with substrate and inhibitors, and predicting binding affinities of inhibitors using computational structural biology tools Salma Banu Rafi, Polina Novichenok, Kolappan Subramaniapillai, Caroline Kisker, Carlos Simmerling, Peter Tonge | ||
| 197 | N-thiolated 2-oxazolidinones: A new and novel class of synthetic antibacterial agents for methicillin-resistant Staphylococcus aureus (MRSA) Rajesh Kumar Mishra, Kevin D Revell, Cristina Coates, Edward Turos, Sonja Dickey, Daniel V. Lim | ||
| 198 | Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents Yang Helen Wang, Edward Turos, Kerriann Robyn Greenhalgh, Suresh Kumar Reddy Guntireddygari, Sonja Dickey, Daniel V. Lim | ||
| 199 | Synthesis and antimicrobial properties of novel S-nitroso β-lactams Maya Kostova, Balbina Plotkin, Monika Konaklieva | ||
| 200 | Photoactive analogues of farnesyl diphosphate for studying protein prenylation Juhua Xu, Olivier Henry, Mark D. Distefano | ||
| 201 | Synthesis of novel bicyclic and tricyclic aldehydes for the preparation of 6-methylidene penem derivatives: A novel class of broad spectrum beta-lactamase inhibitors Osvaldo dos Santos, Tarek S. Mansour, Aranapakam Venkatesan, Fuk-Wah Sum, Yansong Gu, Lijing Chen, Zhong Li, Frank Lin, Gulnaz Khafizoa, Takao Abe, Hideki Ushirogochi, Itsuk Yamamura, Toshio Kumagai | ||
| 202 | Combinatorial library synthesis and biological evaluation of sets of novel ß-lactamase inhibitors Qin Sun, H. Mario Geysen | ||
| 203 | Penicillin bound nanoparticles: A promising new way to save old antibiotics Suresh Kumar Reddy Guntireddygari, Praveen Ramaraju, Edward Turos, Sonja Dickey, Daniel V. Lim | ||
| 204 | Reviving the clinical efficacy of kanamycin-B: Design and synthesis of novel kanamycin analogs and studies of their antibacterial activity against aminoglycoside resistant bacteria Ravi Rai, Cheng-Wei Tom Chang | ||
| 205 | Design and synthesis of novel aminoglycosides and their antibacterial studies against aminoglycoside resistant bacteria Ravi Rai, Cheng-Wei Tom Chang | ||
| 206 | Isolation, characterization, and enhanced antibacterial activity of components from Lomatium californicum Shen-Chieh Chou, Molly C. Everngam, John J. Beck | ||
| 207 | Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase: 2'- and 4'-Substituted triclosan derivatives Joel S. Freundlich, John W. Anderson, Dimitri Sarantakis, Hong-Ming Shieh, Edinson Lucumi, Mack Kuo, Min Yu, Luchezar Karagyozov, Guy A. Schiehser, David P. Jacobus, William R. Jacobs Jr., David A. Fidock, James C. Sacchettini | ||
| 208 | Designing water soluble dendritic amphiphiles for microbiocidal applications Andre A. Williams, Eko, W. Sugandhi, Richard, V. Macri, Richard D. Gandour, Joseph, O. Falkinham | ||
| 209 | Design, development and synthesis of curcumin bioconjugates and their antibacterial and antifungal activity Satyendra Mishra, Upma Narain, Roli Mishra, Krishna Misra | ||
| 210 | Paper Withdrawn | ||
| 211 | Bis-indoloquinolines: New antiinfective agents with low cytotoxicity Seth Y. Ablordeppey, Xue Y. Zhu, Melissa Jacob, Shabana I. Khan, Larry A. Walker | ||
| 212 | Design and synthesis of novel thieno[2,3-d]pyrimidine derivatives as potential anti-bacterial agents D. Ashok, Satish Goud Puppali, Mallikarjun Goud Puppali | ||
| 213 | New scaffold for polyvalent designs of antimicrobial peptides Zhigang Liu, Heather Deshazer, Chunhui Zhou | ||
| 214 | Targeting the rhl quorum sensing cascade in Pseudomonas aeruginosa: C4 library of autoinducer analogs Geetanjali J Jog, Hiro-aki Suga | ||
| 215 | Biologically active bis-(hinokitiolato)copper(II) complexes GM. Arvanitis, M.E. Berardini, C. A. Heyer, S.Y. Kim, Douglas M. Ho | ||
| 216 | Chalcogenoxanthylium photosensitizers for use in photodynamic therapy (PDT) and photodynamic purging of blood-borne viral and bacterial pathogens David J Donnelly, Michael R. Detty, Scott L Gibson, Russell Hilf, Stephen J Wagner, Andrey Skripchenko | ||
| 217 | The development of photoactivated caged biocides Robert G. Brinson, Sarah L Leonard, Paul B. Jones | ||
| 218 | Polymer nanostructures in drug delivery: Treatment and prevention of burn wound infections Kerriann Robyn Greenhalgh, Edward Turos, Yang Helen Wang, G. Suresh Kumar Reddy, Sonja Dickey | ||
| 219 | Studying the interactions of toxic metals with protein tyrosine kinases Yousef Ahmadibeni, Keykavous Parang, Millie White, Gongqin Sun | ||
| 220 | Studies on the relationship between the structural and electronic parameters of some imido- substituted 2-chloro-1,4-naphthoquinones and their biological activities Serenella Linares, Vernon R. Morris, Oladapo Bakare | ||
| 221 | Design of C1 domain-containing isozyme-specific ligands guided by the bioassay of diacylglycerol lactone libraries Dehui Duan, Christopher C. Lai, James A. Kelley, Nancy Lewin, Peter M Blumberg, Victor E. Marquez | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005