Transition metal-catalyzed multicomponent cycloadditon reactions as a synthetic entry into medium-sized rings

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Matthew J. Kier, Kristina Hadlich, khadlich@goucher.edu, and George E. Greco, ggreco@goucher.edu. Department of Chemistry, Goucher College, 1021 Dulaney Valley Road, Baltimore, MD 21204
This presentation details the progress of research directed towards the synthesis of medium-sized rings through transition metal-catalyzed [4+4+1] and [4+4+2] cycloaddition reactions. Related results to be presented include the elucidation of the ring-junction stereochemistry of 7-8 bicyclic carbocycles produced through a Ni-catalyzed [4+4] cycloaddition.