From isofagomine to noeuromycin. A quest for stronger glycosidase inhibitors

CARB 29

Mikael Bols, mb@chem.au.dk, Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus, Denmark
Isofagomine is a potent glycosidase inhibitor discovered by our group in 1994(1). The talk will describe our recent work on creating improved inhibitors based on the isofagomine core structure.

(1) Jespersen, T. M.; Dong, W.; Skrydstrup,T.; Sierks, M.R.; Lundt, I.; Bols, M. "Isofagomine, a Potent New Glycosidase Inhibitor." Angew. Chem. Int. Ed. Engl. 1994 33 1778-1779.

 

Iminosugars: Therapeutic Potential
8:30 AM-12:10 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- 202A, Oral

Division of Carbohydrate Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005