Development of a fluorescent Li+ dye and investigation of its binding and fluorescence properties

ORGN 612

Prakash B. Sanjeevaiah, psanjee@luc.edu, Duarte Mota de Freitas, David S Crumrine, Christopher Malarkey, Monali Patel, and Ricky Rezko. Department of Chemistry, Loyola University Chicago, 6525N Sheridan Road, Chicago, IL 60626
Bipolar disorder is a devastating mental illness with considerable morbidity and mortality. Lithium salts are some of the most effective treatments for bipolar disorder; however, the mechanisms responsible for their therapeutic effects remain to be elucidated. We will present a novel approach for studying the pharmacological mechanism of Li+, which involves the development of a crown ether-based fluorescent dye. The synthesis of the fluorophore dye, its sensitivity for binding Li+ at therapeutic concentrations, its specificity for binding Li+ in the presence of physiological levels of Ca2+ and Mg2+, and its fluorescence properties will be discussed.
 

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005