ORGN 177 |
| SCH 351448 is a 28-membered macrocyclic dilactone, a novel activator of low-density lipoprotein receptor promoter. Key steps in our synthetic approach include applications of the recently developed asymmetric allyl- and crotylsilane reagents, and a new protodesilylative version of the tandem silylformylation/allylsilylation reaction which provides an efficient synthesis of 1,5-syn diols. The total synthesis of SCH 351448 will be described. |
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New Reactions and Methodology, Materials, Total Synthesis, Process R&D
8:00 PM-10:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |