ORGN 443 |
| The ability of cells to regulate osmotic pressure and other metabolic functions is controlled by ion flux across the cellular membrane. Ion transport is regulated by a battery of membrane protein channels, each regulating specific ions. Malfunctions of ion channels result in disease states. Our goal is the design and synthesis of compounds having the ability to transport anions across a phospholipid bilayer via channel or carrier mechanism. We previously reported a 1,3-alternate butylamdide calix[4]arene and its acyclic analogs ability to form chloride selective ion channels. We now report additional calix[4]arene confirmations and confirmationally ridged tripodal scaffolds activities for chloride transport. |
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |